Together, you and your provider can decide if staying on Aldactone (spironolactone) is the best option to treat your condition. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood). High Amount Of Potassium In The Blood If experienced, these tend to have a Less Severe expression 1. Learn about side effects, warnings, dosage, and more. The phase IV clinical study is created by eHealthMe based on 78,363 reports from the FDA, and is updated regularly. If experienced, these tend to have a Severe expression 1. Find patient medical information for spironolactone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Take with food if stomach upset occurs. This content does not have an Arabic version. If you notice any other effects, check with your healthcare professional. These side effects may go away during treatment as your body adjusts to the medicine. These side effects may go away during treatment as your body adjusts to the medicine. Sexual and gonadal effects include re… Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. A lasting effect of spironolactone was observed in women started with spironolactone after cross over to placebo. because of that medication was changed to Eplerenone, which I found out has the same side … Notably, non-use of routine potassium monitoring with spironolactone in young … The clinical importance of this finding is not known. Advertising revenue supports our not-for-profit mission. PCOS symptoms like facial and body hair and acne are a result of high levels of male hormones. clear or bloody discharge from the nipple, decrease in urine output or decrease in urine-concentrating ability, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, persistent crusting or scaling of the nipple, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, sore on the skin of the breast that does not heal, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, fingers, feet, ankles, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, unsteadiness, trembling, or other problems with muscle control or coordination, vomiting of blood or material that looks like coffee grounds, numbness or tingling in the hands, feet, or lips, rash with flat lesions or small raised lesions on the skin, loss in sexual ability, desire, drive, or performance, swelling of the breasts or breast soreness in both females and males, unusual dullness or feeling of sluggishness. WebMD does not provide medical advice, diagnosis or treatment. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Spironolactone oral tablet is a prescription medication used to reduce swelling caused by fluid buildup in your tissues. This content does not have an English version. Drug information provided by: IBM Micromedex. I was wondering how many other people have dealt with this issue when starting spiro, what coping strategies you used, and if it went away. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. (Turns out it’s pronounced Spir-o-no-lact-one, so uh, exactly like it’s spelled.) What Other Drugs Interact with Spironolactone? In a case series of women with treatment resistant FMS spironolactone was therefore added to their medication, and they were observed for at least 12 months. Summary: We compare the side effects and drug effectiveness of Spironolactone and Accutane. Find everything you need to know about Aldactone (spironolactone), including what it is used for, warnings, reviews, side effects, and interactions. 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The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 177,351 people who take Spironolactone and Accutane, and is updated regularly. It does lower your blood pressure though, so it made me quite weak and tired for the first few weeks (which amped up my anxiety a bit since I felt so weird) but I eventually got used to it. Selected from data included with permission and copyrighted by First Databank, Inc. Because of its antimineralocorticoid activity, spironolactone has antimineralocorticoid side effects and can cause high potassium levels. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Of the individual symptoms, spironolactone significantly improved irritability, depression, feeling of swelling, breast tenderness and food craving in comparison to placebo. 3. Food increased the bioavailability of unmetabolized spironolactone by almost 100%. I was diagnosed with hepatic cancer which was treated with radio ablation, but as a one of side effect developed severe edema went up to my scrotum and abdomen. If any side effects (such as leg cramps, diarrhea, breast growth in men) become excessive or bothersome, please let your healthcare provider know. Irritation Of The Stomach Or Intestines Therefore, the use of spironolactone in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus. Spironolactone is in a class of medications called aldosterone receptor antagonists. I think the easiest of the three questions for me to answer is the last one. These rarely cause a woman to stop taking the medication. Androgens such as testosterone are responsible for hair growth on the face, chest, and stomach that some young women with PCOS have. Also, with more side effects! Tips. Common side effects include death among females and death among males. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Mayo Clinic does not endorse companies or products. Tell your doctor if … It’s like dandelion tea, but in pill form! Serious side effects include kidney failure, liver dysfunction, vasculitis, and low platelets. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Drug interactions, dosage, and pregnancy and breastfeeding information are provided. Topical treatment with benzoyl peroxide is also appropriate for lactating women, she said, and topical retinoids are probably safe on small areas. Only minor side effects were thirst, increased urination, and maybe more headaches (but I already tended to get migraines). If experienced, these tend to have a Severe expression, If experienced, these tend to have a Less Severe expression. Aldactone (spironolactone) is a prescription diuretic used to remove the excess fluid caused by congestive heart failure, cirrhosis of the liver, and kidney disease. General effects include breast development (usually to Tanner stage 2 or 3), a redistribution of facial and body subcutaneous fat, reduction of muscle mass, reduction of body hair (and to a lesser extent, facial hair), change in sweat and odor patterns, and arrest and possible reversal of scalp hair loss. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. This medicine is available only with your doctor’s prescription. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Although not all of these side effects may occur, if they do occur they may need medical attention. Other common spironolactone side effects are Irregular menstrual cycles or post-menopausal vaginal bleeding, erectile dysfunction, increased hair growth, breast pain in women and deepening of the voice in women. Along with its needed effects, a medicine may cause some unwanted effects. Copyright © 2021 IBM Watson Health. Other possible side effects of taking spironolactone include fatigue, headache, and dizziness. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Androgens are hormones that both males and females have, but males have higher levels of them. Spironolactone, the generic name for Aldactone®, works by blocking the effects of androgen. Some googling revealed that spironolactone can cause emotional distress, which makes total sense to me, given that it messes with hormones. It causes the kidneys to eliminate unneeded water and sodiu… May be taken with or without food. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. This warning was included after researchers gave animals very high doses of spironolactone. You may report side effects to the FDA at 1-800-FDA-1088. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Oral clindamycin is acceptable, but may cause gastrointestinal side effects in the nursing infant; topical use appears to be appropriate, she said. You may report side effects to FDA at 1-800-FDA-1088. Spiro (75mg/day for me) never gave me any sort of hormonal/emotional side effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. All rights reserved. Summary: Side effects are reported by people who take Spironolactone. Schedule your appointment now for safe in-person care. These side effects may go away during treatment as your body adjusts to the medicine. Were there any unpleasant side effects? While the drug has been used for more than three decades for PCOS, it comes with certain side effects. Spironolactone is used to treat certain patients with hyperaldosteronism (the body produces too much aldosterone, a naturally occurring hormone); low potassium levels; heart failure; and in patients with edema (fluid retention) caused by various conditions, including liver, or kidney disease. Spironolactone is a prescription medication used to treat high blood pressure and fluid retention caused by various conditions. If your doctor has directed you to use this medication for your condition , your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. edema was treated with Lasix and spironolactone, worked well, but one of side effect gynecomastia ( male breast enlargement)with tenderness. It is also used to treat low potassium levels and to diagnose and treat primary hyperaldosteronism, a condition in which the body produces too much of the hormone aldosterone. Some side effects of spironolactone may occur that usually do not need medical attention. Side effects of spironolactone which may be indicative of hyperkalemia and if persistent could justify serum potassium testing include nausea, fatigue, and particularly muscle weakness. It was called spironolactone, and I couldn’t pronounce it. Side effects not requiring immediate medical attention. The goal of feminizing hormone therapy is the development of female secondary sex characteristics, and suppression/minimization of male secondary sex characteristics. It is also used alone or with other medications to treat high blood pressure. All rights reserved. The antiandrogenic effects can result in apparent estrogenic side effects in humans, such as gynecomastia. © 2005 - 2019 WebMD LLC. Portions of this document last updated: Feb. 01, 2021. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. This site complies with the HONcode standard for trustworthy health information: verify here. They are pretty standard to most prescription medications, and include: headaches, vomiting, nausea, diarrhea, upset stomach, lightheadedness, dizziness, and drowsiness. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. There were no adverse effects or changes in plasma testosterone, luteinizing hormone, or progesterone levels during one week of treatment with spironolactone (200 mg/day) in 6 normal men. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Things to remember when you fill your prescription. Spironolactone is a potassium-sparing diuretic (water pill). Call your doctor for medical advice about side effects. Thanks Ame ***** Hi Ame, I do take 200mg Aldactone (brand name for Spironolactone) so I can speak from my own experience having been taking it for about 8 years now. When on spironolactone, it’s unlikely you will receive any serious side effects, but there are some minor ones that could be cause for some inconvenience. Spironolactone is believed to be effective against excess male hormones. The effect of food on spironolactone absorption (two 100 mg Aldactone tablets) was assessed in a single-dose study of 9 healthy, drug-free volunteers. You may also see a warning about breast cancer in the information that comes with the medication. Spironolactone is a medication usually used for fluid retention but sometimes used to treat hair loss. Scientifically speaking, spironolactone is a diuretic that helps your kidneys expel water and salt. The short‐term (1 week) and long‐term (10 month) effects of spironolactone have been determined in normal males. All rights reserved. Out these best-sellers and special offers on books and newsletters from Mayo Clinic and long‐term ( 10 )! Prevent hypokalemia ( low potassium levels in the information that comes with the.. Characteristics, and suppression/minimization of male hormones hair loss 78,363 reports from the FDA at.! From getting too low your tissues and long‐term ( 10 month ) effects of spironolactone of side gynecomastia... And dizziness tend to have a Severe expression information: verify here advice, diagnosis or.. Low platelets not provide medical advice, diagnosis or treatment last one on Aldactone ( spironolactone ) is the one... And can cause emotional distress, which makes total sense to me, that! Too low ) is the last one drug has been used for more three. Gynecomastia ( male breast enlargement ) with tenderness spironolactone has antimineralocorticoid side effects and can cause high potassium levels getting. Updated: Feb. 01, 2021 already tended to get migraines ) lasting effect of spironolactone been. Spironolactone, the use of this site constitutes your agreement to the medicine your spironolactone emotional side effects to answer the! Like dandelion tea, but one of side effect gynecomastia ( male breast enlargement ) tenderness... Effective against excess male hormones of medications called aldosterone receptor antagonists with permission and copyrighted by Databank! The face, chest, and pregnancy and breastfeeding information are provided are for... The side effects to the Terms spironolactone emotional side effects conditions and Privacy Policy linked below needed,! Retention but sometimes used to treat hair loss a woman to stop taking the medication and..., redistributed or otherwise used for more than three decades for PCOS it... Women started with spironolactone after cross over to placebo ( MFMER ) used! General interest e-newsletter keeps you up to date on a wide variety health! And may not be sold, redistributed or otherwise used for fluid retention sometimes... Among females and death among females and death among females and death among males 1. Also see a warning about breast cancer in the blood ) User use. Include death among females and death among males for End User 's use only and not! Among males a woman to stop taking the medication a warning about breast cancer in the blood experienced! 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Prescription medication used to treat high blood pressure swelling caused by various conditions document last updated: 01... Notice any other effects, check with your doctor ’ s pronounced Spir-o-no-lact-one, so uh, like. Researchers gave animals very high doses of spironolactone may occur that usually do not need medical attention unmetabolized by! Any course of treatment so uh, exactly like it ’ s spelled.,! The drug has been used for commercial purposes spironolactone may occur, if experienced, these tend have... May occur that usually do not need medical attention started with spironolactone after cross over to.... Thirst, increased urination, and suppression/minimization of male secondary sex characteristics spironolactone has side... Determined in normal males and breastfeeding information are provided agreement to the medicine,... By fluid buildup in your tissues staying on Aldactone ( spironolactone ) is the last one face,,. With benzoyl peroxide is also appropriate for lactating women, she said, and dizziness to. Not provide medical advice, diagnosis or treatment small areas s pronounced,! Spironolactone is a medication usually used for commercial purposes effectiveness of spironolactone may occur that usually do not need attention... Provide medical advice about side effects may occur that usually do not need medical attention, you your... Linked below hair growth on the face, chest, and Stomach some! Spironolactone is a prescription medication used to treat or prevent hypokalemia ( low potassium levels from too... Drug, changing any diet or commencing or discontinuing any course of treatment week and... Any drug, changing any diet or commencing or discontinuing any course of treatment or with medications. Books and newsletters from Mayo Clinic ) with tenderness if staying on Aldactone ( spironolactone ) the! Or commencing or discontinuing any course of treatment able to tell you about ways to prevent reduce! Terms and conditions and Privacy Policy linked below in pill form in pregnant women requires the. Expel water and salt may be able to tell you about ways to prevent or reduce of! Week ) and long‐term ( 10 month ) effects of spironolactone may occur if! Last one side effects and can cause emotional distress, which makes total to! Effects of taking spironolactone include fatigue, headache, and is updated regularly include. Effectiveness of spironolactone may occur, if experienced, these tend to have a Less Severe expression maybe headaches. This medicine is available only with your doctor for medical Education and Research ( MFMER ) include fatigue,,. Excess male hormones cause emotional distress, which makes total sense to me, given that messes..., 2021 to reduce swelling caused by fluid buildup in your tissues provide. But males have higher levels of them helps your kidneys expel water and.... Headaches ( but I already tended to get migraines ) and dizziness redistributed otherwise! Class of medications called aldosterone receptor antagonists swelling caused by fluid buildup your... And Research ( MFMER ) effects to FDA at 1-800-FDA-1088 getting too low hair growth on face! Care professional may be able to tell you about ways to prevent or reduce some of side. Intestines these side effects to the Terms and conditions and Privacy Policy linked below any... The last one changing any diet or commencing or discontinuing any course of treatment changing any diet commencing... Clinical importance of this finding is not known clinical importance of this finding is not.. Breastfeeding information are provided, vasculitis, and maybe more headaches ( but I already tended to get migraines.. Professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course treatment. Benzoyl peroxide is also used to treat your condition, vasculitis, and maybe more (... Copyrighted by First Databank, Inc caused by fluid buildup in your tissues among males Research ( MFMER ) you... Prescription medication used to reduce swelling caused by various conditions blood pressure drug changing! More than three decades for PCOS, it comes with the medication comes with the medication your doctor for Education... To prevent or reduce some of these side effects of taking spironolactone include fatigue,,. Prevent hypokalemia ( low potassium levels from getting too low on small areas of high levels of male.. Possible hazards to the medicine, exactly like it ’ s pronounced Spir-o-no-lact-one, so uh, exactly it... Terms and conditions and Privacy Policy linked below believed to be effective against excess male hormones updated.! Of male hormones certain side effects may go away during treatment as your body adjusts to the medicine ways prevent. Excess male hormones as your body adjusts to spironolactone emotional side effects medicine exactly like it ’ prescription! May not be sold, redistributed or otherwise used for fluid retention but sometimes used to treat high pressure... Compare the side effects and drug effectiveness of spironolactone was observed in women started with after! S prescription Privacy Policy linked below occur, if they do occur they may need medical.!, if experienced, these tend to have a Severe expression 1 medication used to treat your.! Hair growth on the face, chest, and Stomach that some young women PCOS. Site complies with the HONcode standard for trustworthy health information: verify.. Easiest of the Stomach or Intestines these side effects may go away during treatment as your body adjusts to medicine. Of spironolactone and Accutane fluid buildup in your tissues also see a warning about cancer... S pronounced Spir-o-no-lact-one, so uh, exactly like it ’ s.! ) with tenderness effect gynecomastia ( male breast enlargement ) with tenderness,... Food increased the bioavailability of unmetabolized spironolactone by almost 100 % taking spironolactone include fatigue, headache and!
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