Serotonin syndrome consists of symptoms such as mental status changes (e.g., agitation, confusion, hallucinations), diaphoresis, hyperreflexia, hypertension, diarrhea, fever, tremor, and, in some instances, respiratory failure. This interaction requires a dose adjustment of rizatriptan when it is given concurrently with propranolol. Symptoms may occur hours to days after concomitant use, particularly after dose increases. Send the page ""
The 10-mg dose may provide... 3 DOSAGE FORMS & STRENGTHS Monitor for potential serotonin-related side effects. Some patients had used the combination previously without incident when serotonin syndrome occurred. Inform patients taking this combination of the possible increased risk and monitor for the emergence of serotonin syndrome. Rizatriptan should be used with extreme caution in patients with cerebrovascular disease, including intracranial bleeding, stroke or transient ischemic attacks, due to the vasospastic effects of 5-HT agonists. Symptoms may occur hours to days after concomitant use, particularly after dose increases. Published interaction reports between intravenously administered methylene blue and serotonergic psychiatric agents have documented symptoms including lethargy, confusion, delirium, agitation, aggression, obtundation, myoclonus, expressive aphasia, hypertonia, pyrexia, elevated blood pressure, seizures, and/or coma. Inform patients taking this combination of the possible increased risk and monitor for the emergence of serotonin syndrome. Not a Member? Rizatriptan is contraindicated in basilar/hemiplegic migraine because safety and efficacy have not been established. Desvenlafaxine: (Moderate) Because of the potential risk and severity of serotonin syndrome, caution should be observed when administering desvenlafaxine with other drugs that have serotonergic properties such as serotonin-receptor agonists (e.g., almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan). ... and share it with your doctor and pharmacist. Symptoms may occur hours to days after concomitant use, particularly after dose increases. The generic name of Rizatriptan Benzoate is rizatriptan benzoate. Symptoms may occur hours to days after concomitant use, particularly after dose increases. It is not known if patients receiving other serotonergic agents with intravenous methylene blue are at a comparable risk or if methylene blue administered by other routes (e.g., orally, local injection) or in doses less than 1 mg/kg IV can produce a similar outcome. Tricyclic antidepressants inhibit norepinephrine and serotonin uptake, but rarely cause serotonin syndrome when used alone. If your symptoms are only partly relieved, or if your headache comes back, adults may take another dose at least 2 hours after the first dose. Symptoms may occur hours to days after concomitant use, particularly after dose increases. Patients receiving serotonergic drugs in combination should be informed of the signs and symptoms of serotonin syndrome. ergotamine, triptans, opioids) for 10 or more days per month consider withdrawal of the overused drugs and treatment of withdrawal symptoms. Symptoms may occur hours to days after concomitant use, particularly after dose increases. Tricyclic antidepressants inhibit norepinephrine and serotonin uptake, but rarely cause serotonin syndrome when used alone. Cases of serotonin syndrome have been reported, primarily following administration of standard infusions of methylene blue (1 to 8 mg/kg) as a visualizing agent in parathyroid surgery, in patients receiving selective serotonin reuptake inhibitors, serotonin/norepinephrine reuptake inhibitors, or clomipramine. Discontinue all serotonergic agents and initiate symptomatic treatment if serotonin syndrome occurs. Additive serotonergic effects, including serotonin syndrome, may also occur. 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